TypeScript's type inference is powerful but can struggle with complex or deeply nested generics. If the type inference fails, the compiler might throw an error or assign `any`, which defeats the purpose of using TypeScript. One solution is to simplify your type declarations or break them into smaller, more manageable pieces. Alternatively, you can use explicit type annotations or helper types to guide TypeScript’s inference. Recursive types or generic constraints can also confuse the compiler, so rewriting these for clarity can help. Balancing type inference and explicit annotations allows you to maintain type safety while avoiding issues with overly complex generic structures.