Sync issues between GitHub Desktop and a remote repository often stem from uncommitted local changes or temporary network issues. To start, ensure all local changes are committed and staged before attempting to sync. GitHub Desktop may also display status messages, offering insights into specific conflicts or errors. Network connectivity is a common factor, so testing the internet connection or retrying in a different network environment may help. Additionally, outdated authentication tokens may interrupt the sync process; refreshing the token within GitHub Desktop settings can often restore proper functionality. By addressing these areas, you can resolve sync problems and maintain a seamless workflow between GitHub Desktop and your remote repository.