When dealing with large arrays in Node.js, attempting to load and process everything at once can lead to memory overload or performance bottlenecks. A more efficient approach is to use generators or process the data in chunks. Generators allow you to lazily evaluate elements one at a time, avoiding the need to load the entire array into memory at once. Alternatively, if the array is coming from an external source like a file or database, consider using streams to process the data incrementally. This way, your app can handle large datasets without running out of memory, ensuring better performance and stability under load.