If your TypeScript server hangs after a few minutes of running, it’s likely due to a few common causes, including unhandled promises, memory leaks, or blocking code. Unhandled promise rejections can cause parts of your application to stop responding, so make sure to catch all promises using `.catch()` or `try/catch` with `async/await`. Memory leaks occur when objects are unintentionally kept in memory, leading to high memory usage over time and eventual freezing. Tools like Node.js’s `--inspect` flag and Chrome DevTools can help you analyze memory usage and detect leaks. Another potential issue is synchronous code that blocks the event loop, preventing it from handling other requests. You can identify blocking code using performance monitoring tools and refactor long-running synchronous operations into smaller asynchronous tasks or offload them to worker threads. Regularly monitoring CPU and memory usage and analyzing the server’s event loop behavior can prevent these hangs and ensure smooth operation.