Print-on-demand businesses often face challenges with profitability because of high production costs and low margins. To increase your profits, look for ways to reduce costs, such as negotiating better rates with your supplier or offering products that are cheaper to produce. Another issue could be weak branding. Ensure your designs are unique and that your brand stands out in a crowded market. Lastly, ineffective marketing is a common hurdle. Promote your products through targeted ads, influencer marketing, and social media to reach more customers and boost sales.